PE634010: α-Man-6-phosphate-PEG3-Azide (Disodium Salt)

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Description

PE634010: α-Man-6-phosphate-PEG3-Azide (Disodium Salt)C12H22N3Na2O11P 461. 27 An mannose 6 phosphate (Man6P) ligand, supplied as the disodium salt, equipped with an azide handle through a hydrophilic PEG3 spacer. The terminal azide couples to alkynes via copper catalyzed azide alkyne cycloaddition (CuAAC) or to DBCO and related strained alkynes via copper free click chemistry, forming stable 1,2,3 triazole linkages. This compound enables the construction of lysosome targeted therapeutics and research

N-Cbz-6-aminohexyl

5-a]pyrazin-1-yl]-N-2-pyridinyl-benzamide

/ MUC1(126-149-Cys)-STn(131

TF-antigen

forming stable 1

Heparan sulfate (HS) and heparin are sulfated glycosaminoglycans found as components of proteoglycans

/ α-D-Man-Methyl-Carboxylic Acid (Peracetate) / Carboxymethyl 2

α-L-Rha-Bu-CO2H

Fmoc-Ser(β-D-Maltobiose)-OH

UniProt position 53-57

UniProt position 334-348

95 / MUC1 (UniProt ID P15941) synthetic glycopeptide fragment (Pro126-Gly149