ES031000: 4-Methylumbelliferyl α-N-glycolylneuraminic acid – holyfamilyhelp.us

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ES031000: 4-Methylumbelliferyl α-N-glycolylneuraminic acid

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Description

ES031000: 4-Methylumbelliferyl α-N-glycolylneuraminic acidC21H25NO12 483. 42 A 4 methylumbelliferyl (MU) glycoside of N glycolylneuraminic acid (Neu5Gc), a sialic acid variant carrying an extra hydroxyl on the N acyl group and found in most mammals but not normally in humans. Used as a fluorogenic substrate for sialidases (neuraminidases) with selectivity or preference for Neu5Gc containing sialosides; sialidase catalyzed cleavage of the glycosidic bond releases free Neu5Gc and 4 methylumbelliferone. 4

25 / A β-D-glucose ligand equipped with an azide-functionalized linker through a short propyl spacer

4-Carboxybutyl N-acetyl-α-D-galactosamine

or pentafluorophenyl (PFP) esters and reacted with amine-functionalized platforms or lysine residues on proteins and peptides to form stable amide bonds

used to synthesize peptides modeling early non-enzymatic glycation and advanced glycation end-product (AGE) chemistry

22 / An α-D-galactose ligand equipped with an azide-functionalized linker through a short ethyl spacer

/ Fmoc-Ser(GlcNAc(Ac)3-β-D)-OH / Fmoc-L-Ser(GlcNAc(Ac)3-β-D)-OH

25-Hydroxyergocalciferol-d6

6-tetra-O-acetyl-β-D-glucopyranosyl)-L-tyrosine

2-Azidoethyl β-D-glucopyranoside

43 / A fully unprotected (free amine

C11H20O8 / 280

Fmoc-Thr([Gal β(1-4)Glc]Ac7)-OH

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